Ovariectomy shortens the life span of female mice
نویسندگان
چکیده
منابع مشابه
Ovariectomy shortens the life span of female mice
This study shows that lack of ovarian activity has a negative impact on the life span of female mice. The extent to which this phenomenon could be associated with the anti-inflammatory effect of estrogens was analyzed in metabolic organs and aorta, by quantitative analysis of mRNAs encoding proteins in the inflammatory cascade. We demonstrate that the TNFα, IL-1β, MCP-1, MIP-2 and IL-6 mRNA con...
متن کاملDevelopment of spontaneous mammary tumors over the life-span of the female Charles River (Sprague-Dawley) rat: the influence of ovariectomy, thyroidectomy, and adrenalectomy-ovariectomy.
Several groups of virgin female cesarean-originated, barrier sustained Charles River CD rats were observed for incidence of mammary tumors over their lifespan. Maximum lifespan ranged from 885 to 1040 days. Crude MT3 incidence for all groups was 61 .7 %. When a life table method was used to correct for extraneous deaths, the mean MT incidence for all groups was 71 .5 ± 5.7 %. The age at onset ...
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abstract: about 60% of total premium of insurance industry is pertained?to life policies in the world; while the life insurance total premium in iran is less than 6% of total premium in insurance industry in 2008 (sigma, no 3/2009). among the reasons that discourage the life insurance industry is the problem of adverse selection. adverse selection theory describes a situation where the inf...
15 صفحه اولAging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function
Sphingoid bases (SBs) as bioactive sphingolipids, have been implicated in aging in yeast. However, we know neither how SBs are regulated during yeast aging nor how they, in turn, regulate it. Herein, we demonstrate that the yeast alkaline ceramidases (YPC1 and YDC1) and SB kinases (LCB4 and LCB5) cooperate in regulating SBs during the aging process and that SBs shortens chronological life span ...
متن کاملIdentification of a gene that shortens clonal life span of Paramecium tetraurelia.
We have isolated a Paramecium tetraurelia mutant that divides slowly in daily reisolation cultures and repeats short clonal life spans after successive autogamies. Here we show, using breeding analysis, that a recessive mutation is responsible for the low fission rate and that this low rate is closely related to the short clonal life span. We conclude that a single pleiotropic gene controls the...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2015
ISSN: 1949-2553
DOI: 10.18632/oncotarget.2984